Distinctive features of the respiratory syncytial virus priming loop compared to other non-segmented negative strand RNA viruses.

Distinctive features of the respiratory syncytial virus priming loop compared to other non-segmented negative strand RNA viruses.

De novo initiation by viral RNA-dependent RNA polymerases often requires a polymerase priming residue, located within a priming loop, to stabilize the initiating NTPs. Polymerase structures from three different non-segmented negative strand RNA virus (nsNSV) families revealed putative priming loops...

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Bibliographic Details
Main Authors: Tessa N Cressey, Afzaal M Shareef, Victoria A Kleiner, Sarah L Noton, Patrick O Byrne, Jason S McLellan, Elke Mühlberger, Rachel Fearns
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010451

Internet

https://doi.org/10.1371/journal.ppat.1010451

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