Evaluate the safety and efficacy of dura sealant patch in reducing cerebrospinal fluid leakage following elective cranial surgery (ENCASE II): study protocol for a randomized, two-arm, multicenter trial

Evaluate the safety and efficacy of dura sealant patch in reducing cerebrospinal fluid leakage following elective cranial surgery (ENCASE II): study protocol for a randomized, two-arm, multicenter trial

Abstract Background Cerebrospinal fluid (CSF) leakage is a frequent and challenging complication in neurosurgery, especially in the posterior fossa, with a prevalence of 8%. It is associated with substantial morbidity and increased healthcare costs. A novel dural sealant patch (LIQOSEAL) was develop...

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Main Authors: Andrew P. Carlson, Emma M. H. Slot, Tristan P. C. van Doormaal, on behalf of the ENCASE II study group, E. H. J. Voormolen, J. W. Dankbaar, P. Depauw, B. Brouwers, M. R. Germans, E. Baert, J. Vandersteene, C. F. Freyschlag, J. Freyschlag, C. Thomé, F. Zenga, F. Penner, A. Abdulazim, M. Sabel, M. Rapp, T. Beez, M. Zuccarello, E. Sauvageau, K. Abdullah, B. Welch, D. Langer, J. Ellis, A. Dehdashti, J. VanGompel, B. Bendok, K. Chaichana, J. Liu, A. Dogan, M. K. Lim, M. G. Hayden
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Trials
Subjects:
CSF leakage
Dura
Sealing
Prevention
Online Access:https://doi.org/10.1186/s13063-022-06490-8

Internet

https://doi.org/10.1186/s13063-022-06490-8

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