Protein Kinase A-Mediated Septin7 Phosphorylation Disrupts Septin Filaments and Ciliogenesis

Protein Kinase A-Mediated Septin7 Phosphorylation Disrupts Septin Filaments and Ciliogenesis

Septins are GTP-binding proteins that form heteromeric filaments for proper cell growth and migration. Among the septins, septin7 (SEPT7) is an important component of all septin filaments. Here we show that protein kinase A (PKA) phosphorylates SEPT7 at Thr197, thus disrupting septin filament dynami...

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Bibliographic Details
Main Authors: Han-Yu Wang, Chun-Hsiang Lin, Yi-Ru Shen, Ting-Yu Chen, Chia-Yih Wang, Pao-Lin Kuo
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
septin7
septin filament
primary cilium
protein kinase A
catalytic subunit
Online Access:https://www.mdpi.com/2073-4409/10/2/361

Internet

https://www.mdpi.com/2073-4409/10/2/361

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