Bioinformatic and Mechanistic Analysis of the Palmerolide PKS-NRPS Biosynthetic Pathway From the Microbiome of an Antarctic Ascidian

Bioinformatic and Mechanistic Analysis of the Palmerolide PKS-NRPS Biosynthetic Pathway From the Microbiome of an Antarctic Ascidian

Complex interactions exist between microbiomes and their hosts. Increasingly, defensive metabolites that have been attributed to host biosynthetic capability are now being recognized as products of host-associated microbes. These unique metabolites often have bioactivity targets in human disease and...

Full description

Bibliographic Details
Main Authors: Nicole E. Avalon, Alison E. Murray, Hajnalka E. Daligault, Chien-Chi Lo, Karen W. Davenport, Armand E. K. Dichosa, Patrick S. G. Chain, Bill J. Baker
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Chemistry
Subjects:
marine natural products
macrolide
biosynthetic gene clusters
Antarctic microbiology
trans-AT type I polyketide synthase
secondary metabolites
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.802574/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.802574/full

Similar Items