Autoinducer-2 and bile salts induce c-di-GMP synthesis to repress the T3SS via a T3SS chaperone

Cyclic-di-GMP transduces extracellular stimuli into intracellular responses to modulate important biological processes. Here, the authors show that AI-2 and bile salts induce cyclic-di-GMP synthesis via YeaJ and YedQ, respectively, to repress the T3SS via a cyclic-di-GMP-responsive T3SS chaperone.

Bibliographic Details
Main Authors: Shuyu Li, Hengxi Sun, Jianghan Li, Yujiao Zhao, Ruiying Wang, Lei Xu, Chongyi Duan, Jialin Li, Zhuo Wang, Qinmeng Liu, Yao Wang, Songying Ouyang, Xihui Shen, Lei Zhang
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34607-9