In vitro-in silico study on the influence of dose, fraction bioactivated and endpoint used on the relative potency value of pyrrolizidine alkaloid N-oxides compared to parent pyrrolizidine alkaloids

In vitro-in silico study on the influence of dose, fraction bioactivated and endpoint used on the relative potency value of pyrrolizidine alkaloid N-oxides compared to parent pyrrolizidine alkaloids

Pyrrolizidine alkaloids (PAs) and their N-oxides (PA-N-oxides) are phytotoxins found in food, feed and the environment. Yet, limited data exist from which the relative potency of a PA-N-oxide relative to its corresponding PA (REPPANO to PA) can be defined. This study aims to investigate the influenc...

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Bibliographic Details
Main Authors: Yasser Alhejji, Frances Widjaja, Shenghan Tian, Thomas Hoekstra, Sebastiaan Wesseling, Ivonne M.C.M. Rietjens
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Current Research in Toxicology
Subjects:
7-GS-DHP
Physiologically based kinetic modeling
Pyrrole-protein adducts
Pyrrole-DNA adducts
Rat
Relative potency value
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X24000136

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http://www.sciencedirect.com/science/article/pii/S2666027X24000136

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