A rare codon-based translational program of cell proliferation

A rare codon-based translational program of cell proliferation

Abstract Background The speed of translation elongation is primarily determined by the abundance of tRNAs. Thus, the codon usage influences the rate with which individual mRNAs are translated. As the nature of tRNA pools and modifications can vary across biological conditions, codon elongation rates...

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Bibliographic Details
Main Authors: Joao C. Guimaraes, Nitish Mittal, Alexandra Gnann, Dominik Jedlinski, Andrea Riba, Katarzyna Buczak, Alexander Schmidt, Mihaela Zavolan
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Genome Biology
Subjects:
Cell proliferation
Translation control
Codon usage
Rare codons
Translation elongation
tRNA pools
Online Access:http://link.springer.com/article/10.1186/s13059-020-1943-5

Internet

http://link.springer.com/article/10.1186/s13059-020-1943-5

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