Modulation of immune cell function, IDO expression and kynurenine production by the quorum sensor 2-heptyl-3-hydroxy-4-quinolone (PQS)

Modulation of immune cell function, IDO expression and kynurenine production by the quorum sensor 2-heptyl-3-hydroxy-4-quinolone (PQS)

Many invasive micro-organisms produce ‘quorum sensor’ molecules which regulate colony expansion and may modulate host immune responses. We have examined the ability of Pseudomonas Quorum Sensor (PQS) to influence cytokine expression under conditions of inflammatory stress. The administration of PQS...

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Bibliographic Details
Main Authors: Joy Ogbechi, Yi-Shu Huang, Felix I. L. Clanchy, Eirini Pantazi, Louise M. Topping, L. Gail Darlington, Richard O. Williams, Trevor W. Stone
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
arthritis (including rheumatoid arthritis)
PQS signaling
Indoleamine 2 3-dioxygenase (IDO)
kynurenine (KYN)
tolerance
regulatory T (Treg) cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1001956/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1001956/full

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