Prenatal Choline Supplementation Alters One Carbon Metabolites in a Rat Model of Periconceptional Alcohol Exposure

Prenatal Choline Supplementation Alters One Carbon Metabolites in a Rat Model of Periconceptional Alcohol Exposure

Prenatal alcohol exposure disturbs fetal and placental growth and can alter DNA methylation (DNAm). Supplementation with the methyl donor choline can increase fetal and placental growth and restore DNAm, suggesting converging effects on one-carbon metabolism (1CM). We investigated the impact of peri...

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Bibliographic Details
Main Authors: Sarah E. Steane, Vinod Kumar, James S. M. Cuffe, Karen M. Moritz, Lisa K. Akison
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Nutrients
Subjects:
methyl group
one carbon metabolism
prenatal alcohol
maternal nutrition
placenta
mass spectrometry
Online Access:https://www.mdpi.com/2072-6643/14/9/1874

Internet

https://www.mdpi.com/2072-6643/14/9/1874

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