The effects of Phycocyanobilin on experimental arthritis involve the reduction in nociception and synovial neutrophil infiltration, inhibition of cytokine production, and modulation of the neuronal proteome

The effects of Phycocyanobilin on experimental arthritis involve the reduction in nociception and synovial neutrophil infiltration, inhibition of cytokine production, and modulation of the neuronal proteome

IntroductionThe antinociceptive and pharmacological activities of C-Phycocyanin (C-PC) and Phycocyanobilin (PCB) in the context of inflammatory arthritis remain unexplored so far. In the present study, we aimed to assess the protective actions of these compounds in an experimental mice model that re...

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Main Authors: Javier Marín-Prida, Arielis Rodríguez-Ulloa, Vladimir Besada, Alexey Llopiz-Arzuaga, Nathália Vieira Batista, Ignacio Hernández-González, Nancy Pavón-Fuentes, Érica Leandro Marciano Vieira, Viviana Falcón-Cama, Emilio F. Acosta, Gillian Martínez-Donato, Majel Cervantes-Llanos, Dai Lingfeng, Luis J. González, Julio Raúl Fernández-Massó, Gerardo Guillén-Nieto, Eduardo Pentón-Arias, Flávio Almeida Amaral, Mauro Martins Teixeira, Giselle Pentón-Rol
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
Phycocyanobilin
rheumatoid arthritis
hypernociception
glutamatergic transmission
proteome
neutrophils
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1227268/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1227268/full

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