Decreased β-catenin expression contributes to IFNγ-induced chemokine secretion and lymphocyte infiltration in Hashimoto’s thyroiditis
Hashimoto’s thyroiditis (HT) is a very common organ-specific aut oimmune disease characterized by lymphocyte infiltration and the destruction of thyroid follicular cells (TFCs), in which IFN-γ and chemokines play pivotal roles. Moreover, β-catenin has been implicated in the regulation of T cell in f...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2022-03-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/11/2/EC-21-0451.xml |
| _version_ | 1819349429529870336 |
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| author | Fei Wu Chaoming Mao Xiao Mou Chengcheng Xu Tingting Zheng Ling Bu Xuan Luo Qingyan Lu Xuefeng Wang |
| author_facet | Fei Wu Chaoming Mao Xiao Mou Chengcheng Xu Tingting Zheng Ling Bu Xuan Luo Qingyan Lu Xuefeng Wang |
| author_sort | Fei Wu |
| collection | DOAJ |
| description | Hashimoto’s thyroiditis (HT) is a very common organ-specific aut oimmune disease characterized by lymphocyte infiltration and the destruction of thyroid follicular cells (TFCs), in which IFN-γ and chemokines play pivotal roles. Moreover, β-catenin has been implicated in the regulation of T cell in filtration. However, whether β-catenin is involved in Hashimoto’s thyroiditis is unknown. Here, we examined β-catenin expression in thyroid tissues and investigated its role in the pathogenesis of HT. Th e results showed that β-catenin expression was markedly reduced in the thyroid tissues of HT patients; more importantly, IFN-γ treatment markedly reduced the expression of β-catenin and was accompanied by the secretion of chemokines such as CCL5, CXCL16 , GRO-β, and GRO-γ in TFCs in vitro, which was attributed to GSK-3β/β-catenin signaling pathway activation. Collectively, the decreased expression of β-catenin might contribute to IFNγ-induced chemokine secretion and lymphocyte infiltration in the development of HT. |
| first_indexed | 2024-12-24T19:00:23Z |
| format | Article |
| id | doaj.art-0a2e053913864a9c8e0cba36708ade3b |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-12-24T19:00:23Z |
| publishDate | 2022-03-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-0a2e053913864a9c8e0cba36708ade3b2022-12-21T16:43:13ZengBioscientificaEndocrine Connections2049-36142022-03-0111218https://doi.org/10.1530/EC-21-0451Decreased β-catenin expression contributes to IFNγ-induced chemokine secretion and lymphocyte infiltration in Hashimoto’s thyroiditisFei Wu0Chaoming Mao1Xiao Mou2Chengcheng Xu3Tingting Zheng4Ling Bu5Xuan Luo6Qingyan Lu7Xuefeng Wang8Department of Nuclear Medicine, Yancheng City No. 1 People’s Hospital, Yancheng, China; Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Clinical Medicine, Jiangsu Health Vocational College, Nanjing, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Laboratory Medicine, Xuzhou Central Hospital, Xuzhou, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaHashimoto’s thyroiditis (HT) is a very common organ-specific aut oimmune disease characterized by lymphocyte infiltration and the destruction of thyroid follicular cells (TFCs), in which IFN-γ and chemokines play pivotal roles. Moreover, β-catenin has been implicated in the regulation of T cell in filtration. However, whether β-catenin is involved in Hashimoto’s thyroiditis is unknown. Here, we examined β-catenin expression in thyroid tissues and investigated its role in the pathogenesis of HT. Th e results showed that β-catenin expression was markedly reduced in the thyroid tissues of HT patients; more importantly, IFN-γ treatment markedly reduced the expression of β-catenin and was accompanied by the secretion of chemokines such as CCL5, CXCL16 , GRO-β, and GRO-γ in TFCs in vitro, which was attributed to GSK-3β/β-catenin signaling pathway activation. Collectively, the decreased expression of β-catenin might contribute to IFNγ-induced chemokine secretion and lymphocyte infiltration in the development of HT.https://ec.bioscientifica.com/view/journals/ec/11/2/EC-21-0451.xmlβ-cateninhashimoto’s thyroiditislymphocyte infiltrationifn-γchemokine |
| spellingShingle | Fei Wu Chaoming Mao Xiao Mou Chengcheng Xu Tingting Zheng Ling Bu Xuan Luo Qingyan Lu Xuefeng Wang Decreased β-catenin expression contributes to IFNγ-induced chemokine secretion and lymphocyte infiltration in Hashimoto’s thyroiditis Endocrine Connections β-catenin hashimoto’s thyroiditis lymphocyte infiltration ifn-γ chemokine |
| title | Decreased β-catenin expression contributes to IFNγ-induced chemokine secretion and lymphocyte infiltration in Hashimoto’s thyroiditis |
| title_full | Decreased β-catenin expression contributes to IFNγ-induced chemokine secretion and lymphocyte infiltration in Hashimoto’s thyroiditis |
| title_fullStr | Decreased β-catenin expression contributes to IFNγ-induced chemokine secretion and lymphocyte infiltration in Hashimoto’s thyroiditis |
| title_full_unstemmed | Decreased β-catenin expression contributes to IFNγ-induced chemokine secretion and lymphocyte infiltration in Hashimoto’s thyroiditis |
| title_short | Decreased β-catenin expression contributes to IFNγ-induced chemokine secretion and lymphocyte infiltration in Hashimoto’s thyroiditis |
| title_sort | decreased β catenin expression contributes to ifnγ induced chemokine secretion and lymphocyte infiltration in hashimoto s thyroiditis |
| topic | β-catenin hashimoto’s thyroiditis lymphocyte infiltration ifn-γ chemokine |
| url | https://ec.bioscientifica.com/view/journals/ec/11/2/EC-21-0451.xml |
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