The multifaceted roles of GSDME-mediated pyroptosis in cancer: therapeutic strategies and persisting obstacles

The multifaceted roles of GSDME-mediated pyroptosis in cancer: therapeutic strategies and persisting obstacles

Abstract Pyroptosis is a novel regulated cell death (RCD) mode associated with inflammation and innate immunity. Gasdermin E (GSDME), a crucial component of the gasdermin (GSDM) family proteins, has the ability to convert caspase-3-mediated apoptosis to pyroptosis of cancer cells and activate anti-t...

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Bibliographic Details
Main Authors: Yixiang Hu, Ya Liu, Lijuan Zong, Wenyou Zhang, Renzhu Liu, Qichang Xing, Zheng Liu, Qingzi Yan, Wencan Li, Haibo Lei, Xiang Liu
Format: Article
Language:English
Published: Nature Publishing Group 2023-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06382-y

Internet

https://doi.org/10.1038/s41419-023-06382-y

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