TP53 R273C Mutation Is Associated With Poor Prognosis in LGG Patients

Purpose: With the progress of cancer immunotherapy, hotspot mutations of common oncogenes and tumor suppressors are becoming new potential therapeutic targets. TP53 R273C mutation is one of the hotspot mutations of TP53, and it has a higher frequency in low-grade glioma (LGG). However, the function...

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Bibliographic Details
Main Authors: Jian Zhang, Minglu Liu, Yujie Fang, Jinlong Li, Yin Chen, Shunchang Jiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.720651/full