The Role of Lofexidine in Management of Opioid Withdrawal

Abstract Fear of withdrawal symptoms has been cited by survey respondents as the main reason that they continued to use opioids. Lofexidine is an α2-adrenergic agonist that decreases the sympathetic outflow that results in the characteristic symptoms of opioid withdrawal. A structural analog of clon...

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Bibliographic Details
Main Authors: Joseph V. Pergolizzi, Hani Annabi, Christopher Gharibo, Jo Ann LeQuang
Format: Article
Language:English
Published: Adis, Springer Healthcare 2018-12-01
Series:Pain and Therapy
Subjects:
Online Access:http://link.springer.com/article/10.1007/s40122-018-0108-7