Changes in Striatal Medium Spiny Neuron Morphology Resulting from Dopamine Depletion Are Reversible

Changes in Striatal Medium Spiny Neuron Morphology Resulting from Dopamine Depletion Are Reversible

The classical motor symptoms of Parkinson’s disease (PD) are caused by degeneration of dopaminergic neurons in the substantia nigra, which is followed by secondary dendritic pruning and spine loss at striatal medium spiny neurons (MSN). We hypothesize that these morphological changes at MSN underlie...

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Bibliographic Details
Main Authors: Victoria Sofie Witzig, Daniel Komnig, Björn H. Falkenburger
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cells
Subjects:
spiny projection neurons
striatum
spine density
dendrite morphology
Online Access:https://www.mdpi.com/2073-4409/9/11/2441

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