In silico evaluation of rare codons and their positions in the structure of cytosine deaminase and substrate docking studies
Cytosine deaminase (CDase) is used with 5-fluorocytosine (5FC) for genetic cancer treatment. This approach has several undesirable features, such as a relatively poor turnover of 5FC and low prodrug conversion activities, thus limiting the overall therapeutic response. We previously reported the mol...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2016-06-01
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| Series: | Trends in Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://tips.sums.ac.ir/index.php/TiPS/article/view/69 |