p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response

p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response

Abstract Activation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood. Here, we uncover the critical role of spatio-temporal genome architectu...

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Bibliographic Details
Main Authors: François Serra, Andrea Nieto-Aliseda, Lucía Fanlo-Escudero, Llorenç Rovirosa, Mónica Cabrera-Pasadas, Aleksey Lazarenkov, Blanca Urmeneta, Alvaro Alcalde-Merino, Emanuele M. Nola, Andrei L. Okorokov, Peter Fraser, Mariona Graupera, Sandra D. Castillo, Jose L. Sardina, Alfonso Valencia, Biola M. Javierre
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46666-1

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https://doi.org/10.1038/s41467-024-46666-1

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