Functional Selectivity of Cannabinoid Type 1 G Protein-Coupled Receptor Agonists in Transactivating Glycosylated Receptors on Cancer Cells to Induce Epithelial–Mesenchymal Transition Metastatic Phenotype

Functional Selectivity of Cannabinoid Type 1 G Protein-Coupled Receptor Agonists in Transactivating Glycosylated Receptors on Cancer Cells to Induce Epithelial–Mesenchymal Transition Metastatic Phenotype

Understanding the role of biased G protein-coupled receptor (GPCR) agonism in receptor signaling may provide novel insights into the opposing effects mediated by cannabinoids, particularly in cancer and cancer metastasis. GPCRs can have more than one active state, a phenomenon called either ‘biased...

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Bibliographic Details
Main Authors: David A. Bunsick, Jenna Matsukubo, Rashelle Aldbai, Leili Baghaie, Myron R. Szewczuk
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Cells
Subjects:
cannabinoid
CB1 receptor
Neu1
MMP9
SEAP
RAW-blue
Online Access:https://www.mdpi.com/2073-4409/13/6/480

Internet

https://www.mdpi.com/2073-4409/13/6/480

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