[<sup>18</sup>F]Fluspidine—A PET Tracer for Imaging of σ<sub>1</sub> Receptors in the Central Nervous System

[<sup>18</sup>F]Fluspidine—A PET Tracer for Imaging of σ<sub>1</sub> Receptors in the Central Nervous System

σ<sub>1</sub> receptors play a crucial role in various neurological and neurodegenerative diseases including pain, psychosis, Alzheimer’s disease, and depression. Spirocyclic piperidines represent a promising class of potent σ<sub>1</sub> receptor ligands. The relationship be...

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Bibliographic Details
Main Authors: Friedrich-Alexander Ludwig, Erik Laurini, Judith Schmidt, Sabrina Pricl, Winnie Deuther-Conrad, Bernhard Wünsch
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Pharmaceuticals
Subjects:
σ<sub>1</sub> receptor ligands
σ<sub>1</sub>:σ<sub>2</sub> selectivity
structure–affinity relationships
enantioselective synthesis
pharmacokinetics
logD<sub>7.4</sub> value
Online Access:https://www.mdpi.com/1424-8247/17/2/166

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https://www.mdpi.com/1424-8247/17/2/166

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