[<sup>18</sup>F]Fluspidine—A PET Tracer for Imaging of σ<sub>1</sub> Receptors in the Central Nervous System

[<sup>18</sup>F]Fluspidine—A PET Tracer for Imaging of σ<sub>1</sub> Receptors in the Central Nervous System

σ<sub>1</sub> receptors play a crucial role in various neurological and neurodegenerative diseases including pain, psychosis, Alzheimer’s disease, and depression. Spirocyclic piperidines represent a promising class of potent σ<sub>1</sub> receptor ligands. The relationship be...

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Bibliographic Details
Main Authors:	Friedrich-Alexander Ludwig, Erik Laurini, Judith Schmidt, Sabrina Pricl, Winnie Deuther-Conrad, Bernhard Wünsch
Format:	Article
Language:	English
Published:	MDPI AG 2024-01-01
Series:	Pharmaceuticals
Subjects:	σ<sub>1</sub> receptor ligands σ<sub>1</sub>:σ<sub>2</sub> selectivity structure–affinity relationships enantioselective synthesis pharmacokinetics logD<sub>7.4</sub> value
Online Access:	https://www.mdpi.com/1424-8247/17/2/166

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