CCR2 of Tumor Microenvironmental Cells Is a Relevant Modulator of Glioma Biology

CCR2 of Tumor Microenvironmental Cells Is a Relevant Modulator of Glioma Biology

Glioblastoma multiforme (GBM) shows a high influx of tumor-associated macrophages (TAMs). The CCR2/CCL2 pathway is considered a relevant signal for the recruitment of TAMs and has been suggested as a therapeutic target in malignant gliomas. We found that TAMs of human GBM specimens and of a syngenei...

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Bibliographic Details
Main Authors: Matthäus Felsenstein, Anne Blank, Alexander D. Bungert, Annett Mueller, Adnan Ghori, Irina Kremenetskaia, Olga Rung, Thomas Broggini, Kati Turkowski, Lea Scherschinski, Jonas Raggatz, Peter Vajkoczy, Susan Brandenburg
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
tumor-associated macrophages (TAMs), blood vessel integrity
tumor angiogenesis
CCR2/CCL2 signaling
GBM
Online Access:https://www.mdpi.com/2072-6694/12/7/1882

Internet

https://www.mdpi.com/2072-6694/12/7/1882

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