What is the true discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia?

Dopamine and striatal dysfunctions play a key role in the pathophysiology of Parkinson’s disease (PD) and Dystonia, but our understanding of the changes in the discharge rate and pattern of striatal projection neurons (SPNs) remains limited. Here, we recorded and examined multi-unit signals from the...

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Bibliographic Details
Main Authors: Dan Valsky, Shai Heiman Grosberg, Zvi Israel, Thomas Boraud, Hagai Bergman, Marc Deffains
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/57445