Unraveling the interplay between PKA inhibition and Cdk1 activation during oocyte meiotic maturation

Unraveling the interplay between PKA inhibition and Cdk1 activation during oocyte meiotic maturation

Summary: Oocytes are arrested in prophase I. In vertebrates, meiotic resumption is triggered by hormonal stimulation that results in cAMP-dependent protein kinase (PKA) downregulation leading to Cdk1 activation. Yet the pathways connecting PKA to Cdk1 remain unclear. Here, we identify molecular even...

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Bibliographic Details
Main Authors: Martina Santoni, Ferdinand Meneau, Nabil Sekhsoukh, Sandrine Castella, Tran Le, Marika Miot, Enrico Maria Daldello
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Cell Reports
Subjects:
CP: Cell biology
CP: Developmental biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724001104

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http://www.sciencedirect.com/science/article/pii/S2211124724001104

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