LY2444296, a κ-opioid receptor antagonist, selectively reduces alcohol drinking in male and female Wistar rats with a history of alcohol dependence

LY2444296, a κ-opioid receptor antagonist, selectively reduces alcohol drinking in male and female Wistar rats with a history of alcohol dependence

Abstract Alcohol use disorder (AUD) remains a major public health concern. The dynorphin (DYN)/κ-opioid receptor (KOP) system is involved in actions of alcohol, particularly its withdrawal-associated negative affective states. This study tested the ability of LY2444296, a selective, short-acting, KO...

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Bibliographic Details
Main Authors: Francisco J. Flores-Ramirez, Jessica M. Illenberger, Glenn Pascasio, Lars Terenius, Rémi Martin-Fardon
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Alcohol use disorder
Dynorphin
Kappa-opioid receptor antagonist
LY2444296
Online Access:https://doi.org/10.1038/s41598-024-56500-9

Internet

https://doi.org/10.1038/s41598-024-56500-9

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