B4GALNT1 promotes hepatocellular carcinoma stemness and progression via integrin α2β1-mediated FAK and AKT activation

B4GALNT1 promotes hepatocellular carcinoma stemness and progression via integrin α2β1-mediated FAK and AKT activation

Background & Aims: β-1,4-N-Acetyl-galactosaminyltransferase 1 (B4GALNT1) has been reported to contribute to the development of human malignancies. However, its role in hepatocellular carcinoma (HCC) remains uncharacterised. In this study, we aimed to elucidate the role of B4GALNT1 in HCC ste...

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Bibliographic Details
Main Authors: Yao Tang, Zhijie Xu, Fuyuan Xu, Juan Ye, Jianxu Chen, Jianzhong He, Yingchun Chen, Chunhui Qi, Hongbin Huang, Ruiyang Liu, Hong Shan, Fei Xiao
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:JHEP Reports
Subjects:
B4GALNT1
ITGB1
THBS4
Hepatocellular carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923002343

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http://www.sciencedirect.com/science/article/pii/S2589555923002343

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