Applications of In Silico Models to Predict Drug-Induced Liver Injury

Applications of In Silico Models to Predict Drug-Induced Liver Injury

Drug-induced liver injury (DILI) is a major cause of the withdrawal of pre-marketed drugs, typically attributed to oxidative stress, mitochondrial damage, disrupted bile acid homeostasis, and innate immune-related inflammation. DILI can be divided into intrinsic and idiosyncratic DILI with cholestat...

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Bibliographic Details
Main Authors: Jiaying Lin, Min Li, Wenyao Mak, Yufei Shi, Xiao Zhu, Zhijia Tang, Qingfeng He, Xiaoqiang Xiang
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Toxics
Subjects:
drug-induced liver injury
in silico models
computer algorithm
machine learning
DILIsym
PBPK
Online Access:https://www.mdpi.com/2305-6304/10/12/788

Internet

https://www.mdpi.com/2305-6304/10/12/788

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