| Summary: | Researchers are concentrating on discovering reducing treatments for bacterial infections due to the worrisome and quick rise of drug-resistant microbial-related illnesses. Metallic ion doping and co-doping mesoporous bioactive glass (MBG) can defend against drug-resistant pathogens of <i>Escherichia coli</i> (<i>E. coli</i>) infection of wounds and solve the issues of bone deformities. In this study, un-doped MBG, silver-doped MBG (Ag-doped MBG), cerium-doped MBG (Ce-doped MBG), and silver–cerium co-doped MBG (Ag-Ce co-doped MBG) have been successfully synthesized via the spray pyrolysis method. In addition, various characterization techniques, including X-ray diffraction, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, and nitrogen adsorption–desorption, were used to investigate the phase compositions, surface morphologies, chemical compositions, inner structure morphologies, chemical bonds/functional groups, and specific surface areas, respectively. The antibacterial efficacy against <i>E. coli</i> was assessed using the colony count technique. All types of MBG with Ag, Ce, and Ag-Ce were effective against <i>E. coli</i>. Furthermore, when immersed in simulated body fluid, the MBGs formed hydroxyapatite and could be used to improve bone defects. Only 5.75 mol% Ag-doped MBG showed toxicity in the MTT assay test. According to our analysis, the 80S-Ag-Ce-MBG was the first Ag-Ce co-doped MBG.
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