Efficacy of metformin targets on cardiometabolic health in the general population and non-diabetic individuals: a Mendelian randomization studyResearch in context

Efficacy of metformin targets on cardiometabolic health in the general population and non-diabetic individuals: a Mendelian randomization studyResearch in context

Summary: Background: Metformin shows beneficial effects on cardiometabolic health in diabetic individuals. However, the beneficial effects in the general population, especially in non-diabetic individuals are unclear. We aim to estimate the effects of perturbation of seven metformin targets on card...

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Bibliographic Details
Main Authors: Jie Zheng, Min Xu, Qian Yang, Chunyan Hu, Venexia Walker, Jieli Lu, Jiqiu Wang, Ruixin Liu, Yu Xu, Tiange Wang, Zhiyun Zhao, Jinqiu Yuan, Stephen Burgess, Shiu Lun Au Yeung, Shan Luo, Emma L. Anderson, Michael V. Holmes, George Davey Smith, Guang Ning, Weiqing Wang, Tom R. Gaunt, Yufang Bi
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:EBioMedicine
Subjects:
Metformin targets
Cardiometabolic diseases
General population
Non-diabetic individuals
Mendelian randomization
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423003699

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http://www.sciencedirect.com/science/article/pii/S2352396423003699

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