A TEMPOL and rapamycin loaded nanofiber-covered stent favors endothelialization and mitigates neointimal hyperplasia and local inflammation

A TEMPOL and rapamycin loaded nanofiber-covered stent favors endothelialization and mitigates neointimal hyperplasia and local inflammation

An increased level of reactive oxygen species (ROS) plays a major role in endothelial dysfunction and vascular smooth muscle cell (VSMC) proliferation during in-stent thrombosis and restenosis after coronary artery stenting. Herein, we report an electrospun core-shell nanofiber coloaded with 4-hydro...

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Bibliographic Details
Main Authors: Rui Wang, Jian Lu, Jiasheng Yin, Han Chen, Hongmei Liu, Fei Xu, Tongtong Zang, Rende Xu, Chenguang Li, Yizhe Wu, Qilin Wu, Xiang Fei, Meifang Zhu, Li Shen, Junbo Ge
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-01-01
Series:Bioactive Materials
Subjects:
Electrospun nanofiber membrane
In-stent restenosis
Re-endothelialization
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X22002109

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http://www.sciencedirect.com/science/article/pii/S2452199X22002109

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