A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation

A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation

Abstract Human antigen R (HuR) is a ubiquitously expressed RNA-binding protein, which functions as an RNA regulator. Overexpression of HuR correlates with high grade tumours and poor patient prognosis, implicating it as an attractive therapeutic target. However, an effective small molecule antagonis...

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Bibliographic Details
Main Authors: Alice Fletcher, Dean Clift, Emma de Vries, Sergio Martinez Cuesta, Timothy Malcolm, Francesco Meghini, Raghothama Chaerkady, Junmin Wang, Abby Chiang, Shao Huan Samuel Weng, Jonathan Tart, Edmond Wong, Gerard Donohoe, Philip Rawlins, Euan Gordon, Jonathan D. Taylor, Leo James, James Hunt
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42546-2

Internet

https://doi.org/10.1038/s41467-023-42546-2

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