Electrochemical Determination of Flap Endonuclease 1 Activity Amplified by CRISPR/Cas12a Trans‐Cleavage**

Electrochemical Determination of Flap Endonuclease 1 Activity Amplified by CRISPR/Cas12a Trans‐Cleavage**

Abstract Flap endonuclease 1 (FEN1) participates in the DNA replication and repair processes, which plays an important role in maintaining genome stability. Determination of FEN1 level is highly required for biochemical studies and clinical diagnosis. Herein, a novel electrochemical approach for the...

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Bibliographic Details
Main Authors: Dr. Yulin Zhu, Dr. Jinwen Zhu, Yan Gao, Jiayue Shi, Prof. Dr. Peng Miao
Format: Article
Language:English
Published: Wiley-VCH 2023-04-01
Series:ChemElectroChem
Subjects:
enzyme activity
CRISPR/Cas12a
DNA tetrahedron
triplex-forming oligonucleotide
biosensors
Online Access:https://doi.org/10.1002/celc.202300020

Internet

https://doi.org/10.1002/celc.202300020

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