Pericytes take up and degrade α-synuclein but succumb to apoptosis under cellular stress

Pericytes take up and degrade α-synuclein but succumb to apoptosis under cellular stress

Abstract Parkinson’s disease (PD) is characterised by the progressive loss of midbrain dopaminergic neurons and the presence of aggregated α-synuclein (α-syn). Pericytes and microglia, two non-neuronal cells contain α-syn in the human brain, however, their role in disease processes is poorly underst...

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Bibliographic Details
Main Authors: Taylor J. Stevenson, Rebecca H. Johnson, Jimmy Savistchenko, Justin Rustenhoven, Zoe Woolf, Leon C. D. Smyth, Helen C. Murray, Richard L. M. Faull, Jason Correia, Patrick Schweder, Peter Heppner, Clinton Turner, Ronald Melki, Birger V. Dieriks, Maurice A. Curtis, Michael Dragunow
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-20261-0

Internet

https://doi.org/10.1038/s41598-022-20261-0

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