ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes

ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes

Summary: WNTs play key roles in development and disease, signaling through Frizzled (FZD) seven-pass transmembrane receptors and numerous co-receptors including ROR and RYK family receptor tyrosine kinases (RTKs). We describe crystal structures and WNT-binding characteristics of extracellular region...

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Bibliographic Details
Main Authors: Fumin Shi, Jeannine M. Mendrola, Joshua B. Sheetz, Neo Wu, Anselm Sommer, Kelsey F. Speer, Jasprina N. Noordermeer, Zhong-Yuan Kan, Kay Perry, S. Walter Englander, Steven E. Stayrook, Lee G. Fradkin, Mark A. Lemmon
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Cell Reports
Subjects:
WNT signaling
receptor tyrosine kinases
acylation
growth factor signaling
co-receptor
pseudokinases
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721012985

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http://www.sciencedirect.com/science/article/pii/S2211124721012985

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