Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques

Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques

Abstract Background Alzheimer’s disease (AD) is the most common neurodegenerative disease and type 2 diabetes (T2D) plays an important role in conferring the risk for AD. Although AD and T2D share common features, the common molecular mechanisms underlying these two diseases remain elusive. Methods...

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Bibliographic Details
Main Authors: Teemu Natunen, Henna Martiskainen, Mikael Marttinen, Sami Gabbouj, Hennariikka Koivisto, Susanna Kemppainen, Satu Kaipainen, Mari Takalo, Helena Svobodová, Luukas Leppänen, Benjam Kemiläinen, Simo Ryhänen, Teemu Kuulasmaa, Eija Rahunen, Sisko Juutinen, Petra Mäkinen, Pasi Miettinen, Tuomas Rauramaa, Jussi Pihlajamäki, Annakaisa Haapasalo, Ville Leinonen, Heikki Tanila, Mikko Hiltunen
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Dystrophic neurites
Microglia
PI3K-Akt signaling
Type 2 diabetes
Typical Western diet
Online Access:http://link.springer.com/article/10.1186/s13024-020-00415-2

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http://link.springer.com/article/10.1186/s13024-020-00415-2

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