Repurposed Antimicrobial Combination Therapy: Tobramycin-Ciprofloxacin Hybrid Augments Activity of the Anticancer Drug Mitomycin C Against Multidrug-Resistant Gram-Negative Bacteria

Repurposed Antimicrobial Combination Therapy: Tobramycin-Ciprofloxacin Hybrid Augments Activity of the Anticancer Drug Mitomycin C Against Multidrug-Resistant Gram-Negative Bacteria

The lack of therapeutic options to treat infections caused by multidrug-resistant (MDR) pathogens, especially Gram-negative bacteria, is apparent. Therefore, it is imperative to develop new strategies to address the problem of antimicrobial resistance. Repurposing non-antibiotic commercial drugs for...

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Bibliographic Details
Main Authors: Ronald Domalaon, Derek Ammeter, Marc Brizuela, Bala Kishan Gorityala, George G. Zhanel, Frank Schweizer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Microbiology
Subjects:
adjuvant
antibiotic hybrid
anticancer
antimicrobial
gram-negative bacteria
mitomycin C
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01556/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.01556/full

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