Molecular subtypes of colorectal cancer in pre-clinical models show differential response to targeted therapies: Treatment implications beyond KRAS mutations.

Molecular subtypes of colorectal tumors are associated with prognosis and prediction for treatment benefit from chemotherapy. The purpose of this study was two-fold: 1) to determine the association of colorectal (CRC) molecular subtypes with response to targeted therapies in pre-clinical models and...

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Bibliographic Details
Main Authors: Rekha Pal, Ning Wei, Nan Song, Shaoyu Wu, Rim S Kim, Ying Wang, Patrick G Gavin, Peter C Lucas, Ashok Srinivasan, Carmen J Allegra, Samuel A Jacobs, Soonmyung Paik, John C Schmitz, Katherine L Pogue-Geile
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6097647?pdf=render