The vascular basement membrane as "soil" in brain metastasis.

Brain-specific homing and direct interactions with the neural substance are prominent hypotheses for brain metastasis formation and a modern manifestation of Paget's "seed and soil" concept. However, there is little direct evidence for this "neurotropic" growth in vivo. In c...

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Bibliographic Details
Main Authors: W Shawn Carbonell, Olaf Ansorge, Nicola Sibson, Ruth Muschel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2689678?pdf=render