The impact of early life maternal deprivation on the perineuronal nets in the prefrontal cortex and hippocampus of young adult rats
Early life stress negatively impacts brain development and affects structure and function of parvalbumin immunopositive (PV+) inhibitory neurons. Main regulators of PV+ interneurons activity and plasticity are perineuronal nets (PNNs), an extracellular matrix formation that enwraps PV+ interneurons...
Main Authors: | Ana Jakovljevic, Gorana Agatonovic, Dubravka Aleksic, Milan Aksic, Gebhard Reiss, Eckart Förster, Antonios Stamatakis, Igor Jakovcevski, Joko Poleksic |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-11-01
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Series: | Frontiers in Cell and Developmental Biology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.982663/full |
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