Vaccinia E5 is a major inhibitor of the DNA sensor cGAS

Vaccinia E5 is a major inhibitor of the DNA sensor cGAS

Abstract The DNA sensor cyclic GMP-AMP synthase (cGAS) is critical in host antiviral immunity. Vaccinia virus (VACV) is a large cytoplasmic DNA virus that belongs to the poxvirus family. How vaccinia virus antagonizes the cGAS-mediated cytosolic DNA-sensing pathway is not well understood. In this st...

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Bibliographic Details
Main Authors: Ning Yang, Yi Wang, Peihong Dai, Tuo Li, Christian Zierhut, Adrian Tan, Tuo Zhang, Jenny Zhaoying Xiang, Alban Ordureau, Hironori Funabiki, Zhijian Chen, Liang Deng
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38514-5

Internet

https://doi.org/10.1038/s41467-023-38514-5

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