α7 Nicotinic Agonist AR-R17779 Protects Mice against 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis in a Spleen-Dependent Way

α7 Nicotinic Agonist AR-R17779 Protects Mice against 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis in a Spleen-Dependent Way

The existence of a cholinergic anti-inflammatory pathway negatively modulating the inflammatory and immune responses in various clinical conditions and experimental models has long been postulated. In particular, the protective involvement of the vagus nerve and of nicotinic Ach receptors (nAChRs) h...

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Bibliographic Details
Main Authors: Andrea Grandi, Irene Zini, Lisa Flammini, Anna M. Cantoni, Valentina Vivo, Vigilio Ballabeni, Elisabetta Barocelli, Simona Bertoni
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Pharmacology
Subjects:
intestine
inflammation
α7 nicotinic agonist
α4β2 nicotinic receptors
sulfasalazine
lymph nodes
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00809/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00809/full

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