All-Trans Retinoic Acid Attenuates Transmissible Gastroenteritis Virus-Induced Apoptosis in IPEC-J2 Cells via Inhibiting ROS-Mediated P<sub>38</sub>MAPK Signaling Pathway

All-Trans Retinoic Acid Attenuates Transmissible Gastroenteritis Virus-Induced Apoptosis in IPEC-J2 Cells via Inhibiting ROS-Mediated P<sub>38</sub>MAPK Signaling Pathway

Transmissible gastroenteritis virus (TGEV) can cause diarrhea, dehydration, and high mortality in piglets, which is closely related to intestinal epithelial cell apoptosis caused by TGEV infection. All-trans retinoic acid (ATRA) is the active metabolite of vitamin A, which has antioxidant and anti-a...

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Bibliographic Details
Main Authors: Junning Pu, Daiwen Chen, Gang Tian, Jun He, Zhiqing Huang, Ping Zheng, Xiangbing Mao, Jie Yu, Junqiu Luo, Yuheng Luo, Hui Yan, Bing Yu
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Antioxidants
Subjects:
all-trans retinoic acid
transmissible gastroenteritis virus
apoptosis
oxidative stress
ROS/P<sub>38</sub>MAPK pathway
IPEC-J2 cells
Online Access:https://www.mdpi.com/2076-3921/11/2/345

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https://www.mdpi.com/2076-3921/11/2/345

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