Specific Targeting and Labeling of Colonic Polyps in <i>CPC-APC</i> Mice with Mucin 5AC Fluorescent Antibodies: A Model for Detection of Early Colon Cancer

Specific Targeting and Labeling of Colonic Polyps in <i>CPC-APC</i> Mice with Mucin 5AC Fluorescent Antibodies: A Model for Detection of Early Colon Cancer

Poor visualization of polyps can limit colorectal cancer screening. Fluorescent antibodies to mucin5AC (MUC5AC), a glycoprotein upregulated in adenomas and colorectal cancer, could improve screening colonoscopy polyp detection rate. Adenomatous polyposis coli flox mice with a <i>Cdx2-Cre</i...

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Bibliographic Details
Main Authors: Michael A. Turner, Kristin E. Cox, Shanglei Liu, Nicholas Neel, Siamak Amirfakhri, Hiroto Nishino, Mojgan Hosseini, Joshua A. Alcantara, Amer Ali Abd El-Hafeez, Thinzar M. Lwin, Kavita Mallya, Joseph R. Pisegna, Satish K. Singh, Pradipta Ghosh, Robert M. Hoffman, Surinder K. Batra, Michael Bouvet
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Current Issues in Molecular Biology
Subjects:
colorectal cancer
polyps
fluorescence
fluorescence labeling
mucin
detection
Online Access:https://www.mdpi.com/1467-3045/45/4/219

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https://www.mdpi.com/1467-3045/45/4/219

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