Clinical rel mutations in Staphylococcus aureus prime pathogen expansion under nutrient stress

Clinical rel mutations in Staphylococcus aureus prime pathogen expansion under nutrient stress

ABSTRACT Persistent infection by Staphylococcus aureus has been linked to the bacterial stringent response (SR), a conserved stress response pathway regulated by the Rel protein. Rel synthesizes (p)ppGpp “alarmones” in response to amino acid starvation, which enables adaptation to stress by modulati...

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Bibliographic Details
Main Authors: Edwin Chen, Marla G. Shaffer, Robert E. Bilodeau, Raymond E. West, Patrick J. Oberly, Thomas D. Nolin, Matthew J. Culyba
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mSphere
Subjects:
Staphylococcus aureus
bacteremia
stringent response
persistence
mrsa
Online Access:https://journals.asm.org/doi/10.1128/msphere.00249-23

Internet

https://journals.asm.org/doi/10.1128/msphere.00249-23

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