Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy

Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy

Abstract Tauopathies, including Alzheimer’s disease, are characterized by retinal ganglion cell loss associated with amyloid and phosphorylated tau deposits. We investigated the functional impact of these histopathological alterations in the murine P301S model of tauopathy. Visual impairments were d...

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Bibliographic Details
Main Authors: L. Arouche-Delaperche, S. Cadoni, C. Joffrois, G. Labernede, M. Valet, Q. César, J. Dégardin, S. Girardon, C. Gabriel, S. Krantic, S. Picaud
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Acta Neuropathologica Communications
Subjects:
Retina
Phosphorylated tau
Alzheimer’s disease
P301S mouse
Synapsis
Online Access:https://doi.org/10.1186/s40478-022-01489-3

Internet

https://doi.org/10.1186/s40478-022-01489-3

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