Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy

Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy

Abstract Tauopathies, including Alzheimer’s disease, are characterized by retinal ganglion cell loss associated with amyloid and phosphorylated tau deposits. We investigated the functional impact of these histopathological alterations in the murine P301S model of tauopathy. Visual impairments were d...

Full description

Bibliographic Details
Main Authors:	L. Arouche-Delaperche, S. Cadoni, C. Joffrois, G. Labernede, M. Valet, Q. César, J. Dégardin, S. Girardon, C. Gabriel, S. Krantic, S. Picaud
Format:	Article
Language:	English
Published:	BMC 2023-01-01
Series:	Acta Neuropathologica Communications
Subjects:	Retina Phosphorylated tau Alzheimer’s disease P301S mouse Synapsis
Online Access:	https://doi.org/10.1186/s40478-022-01489-3

Similar Items

Dysregulated Brain Protein Phosphorylation Linked to Increased Human Tau Expression in the hTau Transgenic Mouse Model
by: Isidro Ferrer, et al.
Published: (2022-06-01)

Tau oligomers: the toxic player at synapses in Alzheimer’s disease
by: Marcos Jair Guerrero-Munoz, et al.
Published: (2015-12-01)

Concomitant Retinal Alterations in Neuronal Activity and TNFα Pathway Are Detectable during the Pre-Symptomatic Stage in a Mouse Model of Alzheimer’s Disease
by: Virginie Dinet, et al.
Published: (2022-05-01)

Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice
by: Taiki Kambe, et al.
Published: (2011-06-01)

Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy
by: Tristan Williams, et al.
Published: (2023-06-01)

Biochemical distribution of tau protein in synaptosomal fraction of transgenic mice expressing human P301L tau
by: Naruhiko eSahara, et al.
Published: (2014-03-01)

Sex-Related Motor Deficits in the Tau-P301L Mouse Model
by: Luana Cristina Camargo, et al.
Published: (2021-09-01)

Hyperphosphorylated Human Tau Accumulates at the Synapse, Localizing on Synaptic Mitochondrial Outer Membranes and Disrupting Respiration in a Mouse Model of Tauopathy
by: Andrew J. Trease, et al.
Published: (2022-03-01)

Impact of APOE genotype on prion-type propagation of tauopathy
by: Tristan Williams, et al.
Published: (2022-04-01)

The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer’s disease
by: Yao Sun, et al.
Published: (2020-02-01)

Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration
by: María J. Pérez, et al.
Published: (2018-07-01)

Tauopathy Analysis in P301S Mouse Model of Alzheimer Disease Immunized with DNA and MVA Poxvirus-Based Vaccines Expressing Human Full-Length 4R2N or 3RC Tau Proteins
by: Juan García-Arriaza, et al.
Published: (2020-03-01)

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies
by: Caterina Giacomini, et al.
Published: (2018-05-01)

Antisense Oligonucleotide-Mediated Reduction of HDAC6 Does Not Reduce Tau Pathology in P301S Tau Transgenic Mice
by: Antonio Valencia, et al.
Published: (2021-06-01)

Insulin-Mediated Changes in Tau Hyperphosphorylation and Autophagy in a Drosophila Model of Tauopathy and Neuroblastoma Cells
by: Shreyasi Chatterjee, et al.
Published: (2019-08-01)

Using mass spectrometry to validate mouse models of tauopathy
by: Yan Yan, et al.
Published: (2023-04-01)

Phosphorylated Tau in Alzheimer’s Disease and Other Tauopathies
by: Priyanka Rawat, et al.
Published: (2022-10-01)

Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy
by: Taeko Kimura, et al.
Published: (2018-02-01)

Long COVID as a Tauopathy: Of “Brain Fog” and “Fusogen Storms”
by: Adonis Sfera, et al.
Published: (2023-08-01)

Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer’s disease and tauopathy models
by: Karthikeyan Selvarasu, et al.
Published: (2022-10-01)

Differential Effects of Human P301L Tau Expression in Young versus Aged Mice
by: Holly C. Hunsberger, et al.
Published: (2021-10-01)

Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers
by: Taeko Kimura, et al.
Published: (2024-02-01)

Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning
by: Florian Eckenweber, et al.
Published: (2020-07-01)

Tauopathies: A Distinct Class of Neurodegenerative Diseases
by: Ozansoy M, et al.
Published: (2007-01-01)

Editorial: Tau Protein: Mechanisms From Health to Degeneration
by: Isabel Lastres-Becker, et al.
Published: (2021-11-01)

Regenerating islet-derived 1α (REG-1α) protein increases tau phosphorylation in cell and animal models of tauopathies
by: Mireille Moussaed, et al.
Published: (2018-11-01)

Dl-3-n-Butylphthalide Reduces Cognitive Deficits and Alleviates Neuropathology in P301S Tau Transgenic Mice
by: Yanmin Chang, et al.
Published: (2021-02-01)

Corrigendum: Dl-3-n-Butylphthalide Reduces Cognitive Deficits and Alleviates Neuropathology in P301S Tau Transgenic Mice
by: Yanmin Chang, et al.
Published: (2021-06-01)

Alterations in chromosomal synapses and DNA repair in apoptotic spermatocytes of Mus m. domesticus
by: E. Ayarza, et al.
Published: (2016-06-01)

Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy
by: Yuta Takaichi, et al.
Published: (2020-06-01)

Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms
by: Kaylin Hwang, et al.
Published: (2022-07-01)

Frontotemporal Dementia P301L Mutation Potentiates but Is Not Sufficient to Cause the Formation of Cytotoxic Fibrils of Tau
by: Kuang-Wei Wang, et al.
Published: (2023-10-01)

Functional Interactions of Tau Phosphorylation Sites That Mediate Toxicity and Deficient Learning in Drosophila melanogaster
by: Iason Keramidis, et al.
Published: (2020-10-01)

Essential Role of Astrocytes in Learning and Memory
by: Paula Escalada, et al.
Published: (2024-02-01)

Privación sensorial temprana durante el neurodesarrollo y sus consecuencias cognitivas
by: Juan Felipe Álvarez Restrepo, et al.
Published: (2020-10-01)

“Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies
by: Yuxing Xia, et al.
Published: (2021-06-01)

Zebrafish Models to Study New Pathways in Tauopathies
by: Clément Barbereau, et al.
Published: (2021-04-01)

Tau Protein Modulates Perineuronal Extracellular Matrix Expression in the TauP301L-<i>acan</i> Mouse Model
by: Sophie Schmidt, et al.
Published: (2022-03-01)

Internalization of the Extracellular Full-Length Tau Inside Neuro2A and Cortical Cells Is Enhanced by Phosphorylation
by: Mathilde Wauters, et al.
Published: (2016-08-01)

Neurofascin Is a Novel Component of Rod Photoreceptor Synapses in the Outer Retina
by: Sahar Pourhoseini, et al.
Published: (2021-02-01)