Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism

Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex (PDC), which acts as a central metabolic node...

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Bibliographic Details
Main Authors: Sungmi Park, Jae-Han Jeon, Byong-Keol Min, Chae-Myeong Ha, Themis Thoudam, Bo-Yoon Park, In-Kyu Lee
Format: Article
Language:English
Published: Korean Diabetes Association 2018-08-01
Series:Diabetes & Metabolism Journal
Subjects:
Glycolysis
Metabolism
Mitochondria
Oxidative phosphorylation
Online Access:https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-42-270.pdf

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