Cardiotoxic Effect of Modern Anthracycline Dosing on Left Ventricular Ejection Fraction: A Systematic Review and Meta‐Analysis of Placebo Arms From Randomized Controlled Trials

Cardiotoxic Effect of Modern Anthracycline Dosing on Left Ventricular Ejection Fraction: A Systematic Review and Meta‐Analysis of Placebo Arms From Randomized Controlled Trials

Background Anthracyclines are a key chemotherapeutic agent used against hematological and solid organ malignancies. However, their benefits in cancer survival are limited by cumulative, dose‐related cardiotoxicity. The impact of anthracyclines on left ventricular ejection fraction (LVEF), in the era...

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Bibliographic Details
Main Authors: Prajith Jeyaprakash, Sukhmandeep Sangha, Katherine Ellenberger, Shanthosh Sivapathan, Faraz Pathan, Kazuaki Negishi
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
anthracyclines
cardio‐oncology
cardiotoxicity
left ventricular ejection fraction
meta‐analysis
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.018802

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.120.018802

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