Use of an In Vitro Skin Parallel Artificial Membrane Assay (Skin-PAMPA) as a Screening Tool to Compare Transdermal Permeability of Model Compound 4-Phenylethyl-Resorcinol Dissolved in Different Solvents

Use of an In Vitro Skin Parallel Artificial Membrane Assay (Skin-PAMPA) as a Screening Tool to Compare Transdermal Permeability of Model Compound 4-Phenylethyl-Resorcinol Dissolved in Different Solvents

Absorption through the skin of topically applied chemicals is relevant for both formulation development and safety assessment, especially in the early stages of development. However, the supply of human skin is limited, and the traditional in vitro methods are of low throughput. As an alternative, a...

Full description

Bibliographic Details
Main Authors: Bálint Sinkó, Vivien Bárdos, Dániel Vesztergombi, Szabina Kádár, Petra Malcsiner, Anne Moustie, Chantal Jouy, Krisztina Takács-Novák, Sebastien Grégoire
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceutics
Subjects:
Skin-PAMPA
formulation
skin barrier
permeability
pig skin
safety testing
Online Access:https://www.mdpi.com/1999-4923/13/11/1758

Internet

https://www.mdpi.com/1999-4923/13/11/1758

Similar Items