Quantifying carbon sources for de novo lipogenesis in wild-type and IRS-1 knockout brown adipocytes

Studies were conducted to evaluate the flux of various carbon sources to lipogenesis during brown adipocyte differentiation. 13C labeling and isotopomer spectral analysis quantified the contribution of metabolites to de novo lipogenesis in wild-type (WT) and insulin receptor substrate-1 knockout (KO...

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Bibliographic Details
Main Authors: Hyuntae Yoo, Gregory Stephanopoulos, Joanne K. Kelleher
Format: Article
Language:English
Published: Elsevier 2004-07-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520317880