Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein in Human Embryonic Stem Cells

Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein in Human Embryonic Stem Cells

Oct4 is an important mammalian POU family transcription factor expressed by early human embryonic stem cells (hESCs). The precise level of Oct4 governs the pluripotency and fate determination of hESCs. Several post-translational modifications (PTMs) of Oct4 including phosphorylation, ubiquitination,...

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Bibliographic Details
Main Authors: Byung-Ho Rhie, Ainsley Mike Antao, Janardhan Keshav Karapurkar, Min-Seong Kim, Won-Jun Jo, Suresh Ramakrishna, Kye-Seong Kim
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
CRISPR/Cas9
embryonic carcinoma cells
gene knockout
post-translational modifications
26S proteasome
Online Access:https://www.mdpi.com/1422-0067/22/11/5584

Internet

https://www.mdpi.com/1422-0067/22/11/5584

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